SELECTIVE CYCLIZATION OF 2-PROPARGYLTHIO-6-METHYL-PYRIMIDIN- 4(1 H)-ONE TO THIAZOLO [3,2-a] PYRIMIDIN 7-ONE
نویسندگان: ثبت نشده
چکیده مقاله:
Selective transformation of 2-propargylthio-6-methyl-pyrimidin-4(1H)On e (2) to 3,5-dimethyl-7H-thiazolo [3,2-a] pyrimidin-7-one (3) is performed under the conditionof base catalysis . For elucidation of structure, palladium catalyzed cyclization reaction of (2) was carried out and the structures of the products were assigned (5) and (6). These compounds underwent isomerization to (3) and (4) respectively. From this result, regioselectivity by base catalysis was concluded
منابع مشابه
selective cyclization of 2-propargylthio-6-methyl-pyrimidin- 4(1 h)-one to thiazolo [3,2-a] pyrimidin 7-one
selective transformation of 2-propargylthio-6-methyl-pyrimidin-4(1h)on e (2) to 3,5-dimethyl-7h-thiazolo [3,2-a] pyrimidin-7-one (3) is performed under the conditionof base catalysis . for elucidation of structure, palladium catalyzed cyclization reaction of (2) was carried out and the structures of the products were assigned (5) and (6). these compounds underwent isomerization to (3) and (4) r...
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عنوان ژورنال
دوره 9 شماره 1
صفحات -
تاریخ انتشار 1998-03-01
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